Human health and longevity depend on the development of medicine, and the progress of modern medicine has increasingly depended on the development of biomedical materials and biological instruments. As special functional materials, biomedical materials are new materials used to diagnose, treat, repair or replace damaged tissues, organs or enhance their functions in living organisms. An important branch of materials science. With the vigorous development of biotechnology, biomedical materials have become a hot spot for scientists from all over the world to carry out research and development, and their research and development have been included in the development plan of high-tech key new materials by many countries.

As the most populous country in the world, my country has a huge market potential for biomedical materials. The "Blue Book of Medical Devices: China's Medical Device Industry Development Report (2019)" pointed out that the main revenue of my country's medical device manufacturers reached 638 billion yuan in 2018, and China has developed into the world's second largest medical device market. will exceed one trillion yuan.

Although some fields of biomaterials science and engineering research in my country have reached the international advanced level, the transformation ability of scientific and technological achievements is low, and some related industries have not yet formed innovation-driven development. Universities, research institutes, doctors, entrepreneurs, medical device technical talents and investment institutions are the core forces for the innovation and development of medical devices. However, due to the shortage or dispersion of supporting resources, technology research and development and industrialization are hindered. It is urgent to build a medical device industry platform. Medical device entrepreneurs, technology masters and investment institutions provide a full range of services to accelerate the development and industrialization of medical devices.

Songshan Lake Materials Laboratory provides such a platform for the bone cement material team: introducing high-end biomedical material projects with independent intellectual property rights and high market value from scientific research institutes and small and micro-invasive enterprises, and entering the innovative model factory, Provide an industrialized technology platform and part of the start-up capital to achieve rapid clinical transformation of products.

Orthopedic implant materials, such as bone cement, are one of the mid-to-high-end medical devices that domestic companies still need to make technological breakthroughs. At present, the bone cement market is mainly occupied by brands from Europe and the United States. In 1951, scientists invented PMMA bone cement, namely polymethylmethacrylate cement (PMMA), which is a room temperature self-setting adhesive composed of powder and liquid. This technology was deeply researched and popularized in 1958, and the bone cement-fixed prosthesis replacement was successful. In 1978, it was successfully developed in China and used in clinical practice.

The use of bone cement is more convenient, as long as they are mixed together in a certain proportion and reconciled, the polymerization reaction can occur at room temperature. It starts out like mortar, then like gruel, and then becomes dough, which can be kneaded and extruded into any shape, and finally solidified gradually. The whole process only takes about ten minutes. Doctors place it where the joint is to be replaced before it hardens, and the artificial joint is then fitted. When the reaction is over, the local temperature will rise and it will feel a little hot. At this time, the same strong bone cement as the high-quality building cement successfully inlaid the artificial joint with the human bone and fixed it firmly. After a short period of rehabilitation after surgery, the replaced joint can function. In the case of an artificial hip replacement, you can walk on the ground after short-term rehabilitation. This kind of fixation is quite reliable and can be maintained for more than ten years or even twenty years.

Due to its many advantages, PMMA bone cement has always been the most widely used material, which is widely used in artificial joint replacement and as an orthopaedic filling and fixation material to repair various complex bone defect wounds. Especially in the treatment of vertebral body compression fractures, it can quickly stabilize the injured vertebral body and relieve the symptoms of patients. However, since PMMA bone cement cannot be degraded and lack biological activity, it cannot organically combine with the host bone tissue. After implantation into the human body, it has poor fusion with the surrounding bone tissue, which is not conducive to the adhesion and growth of bone cells; nor can it promote the mesenchyme. Stem cells differentiate into osteocytes and chondrocytes to induce bone tissue growth; long-term use can easily lead to loosening and inflammation of the implant, resulting in implant failure. Bone cement is an organic polymer compound material, which is obtained by polymerization of monomer methyl methacrylate and polymethyl methacrylate. One of the monomers has strong cytotoxicity, and after entering the blood, it will cause the blood pressure to drop, the pulse to increase, collapse, and even cardiac arrest. In addition, because PMMA bone cement is injected into the bone marrow cavity and releases a lot of heat during the coagulation process, the residual blood and fat in the bone marrow cavity expands after being heated, causing the pressure in the medullary cavity to increase, which will cause fat to enter the blood vessels and cause embolism.

In recent years, new bone cements made of hydroxyapatite have been used clinically to some extent. Calcium Phosphate Cement (CPC) was first proposed by Brown and Chow in the 1980s in the United States. CPC bone cement is made of The mixture of one or more calcium phosphate powders reacts with the liquid phase for hydration and can self-solidify under physiological conditions. For example, hydration reaction occurs under the conditions of temperature (37°C) and humidity (100%), and the cured product hydroxyapatite similar to human bone tissue can be obtained, so it has certain degradability and good biocompatibility. Its mechanical properties and degradation properties still need to be improved, which also directly affects its promotion in clinical applications.